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In The Lancet, the RECOVERY Collaborative Group report the clinical results from the RECOVERY trial—one of the largest and most productive platform trials to date among patients admitted to hospital with COVID-19—on the effectiveness of lopinavir–ritonavir treatment. Compared with the first randomised trial to investigate lopinavir–ritonavir in patients with COVID-19 by Cao and colleagues (including […]

Summary Background Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. Here, we report the results of a randomised trial to assess whether lopinavir–ritonavir improves outcomes in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, platform trial, a range